Biology:PGPEP1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

The PGPEP1 gene in humans encodes the enzyme Pyroglutamyl-peptidase I.

Further reading

• Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
• Valdivia A; Irazusta J; Fernández D et al. (2005). "Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia". Regul. Pept. 122 (2): 79–84. doi:10.1016/j.regpep.2004.05.005. PMID 15380924. 
• "VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein". Clin. Cancer Res. 10 (5): 1826–34. 2004. doi:10.1158/1078-0432.CCR-0914-3. PMID 15014037. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Dando PM; Fortunato M; Strand GB et al. (2003). "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme". Protein Expr. Purif. 28 (1): 111–9. doi:10.1016/S1046-5928(02)00632-0. PMID 12651114. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Gil J; Larrinaga G; Meana JJ et al. (2002). "Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study". Neuropeptides 35 (5–6): 276–84. doi:10.1054/npep.2001.0870. PMID 12030812. 
• Charli JL; Mendez M; Vargas MA et al. (1990). "Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices". Neuropeptides 14 (3): 191–6. doi:10.1016/0143-4179(89)90044-9. PMID 2575716.