Biology:Pyroglutamyl-peptidase I
From HandWiki
| Pyroglutamyl-peptidase I | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.19.3 | ||||||||
| CAS number | 9075-21-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Pyroglutamyl-peptidase I (EC 3.4.19.3, also known as Pyrrolidonyl peptidase, is an enzyme (a cysteine peptidase) found in bacteria, plants and animals.
It can be used to distinguish certain Streptococcal organisms.[1]
Other names are 5-oxoprolyl-peptidase, pyrase, pyrrolidonyl arylamidase, pyroglutamate aminopeptidase, pyroglutamyl aminopeptidase, L-pyroglutamyl peptide hydrolase, pyrrolidone-carboxyl peptidase, pyrrolidone-carboxylate peptidase, pyrrolidonyl peptidase, L-pyrrolidonecarboxylate peptidase, pyroglutamidase, pyrrolidonecarboxylyl peptidase) is an enzyme.[2][3][4][5] This enzyme catalyses the following chemical reaction
- Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Human gene
See also
References
- ↑ "Measurement of constitutive L-pyrrolidonyl peptidase activity from Streptococcus and Enterococcus using tetrazotized 0-dianisidine". Antonie van Leeuwenhoek 55 (3): 269–75. March 1989. doi:10.1007/BF00393855. PMID 2569292.
- ↑ "Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme". Biochim. Biophys. Acta 791 (2): 117–122. 1984. doi:10.1016/0167-4838(84)90001-3.
- ↑ "Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins". Proteins 20 (1): 34–51. September 1994. doi:10.1002/prot.340200106. PMID 7824521.
- ↑ "Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus". Gene 166 (1): 95–9. December 1995. doi:10.1016/0378-1119(95)00561-0. PMID 8529900.
- ↑ "Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase". Journal of Bacteriology 178 (11): 3308–13. June 1996. PMID 8655512.
External links
- Pyroglutamyl-peptidase+I at the US National Library of Medicine Medical Subject Headings (MeSH)
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