Biology:PLK2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. [supplied by OMIM]

Further reading

• "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity.". EMBO J. 18 (20): 5528–39. 1999. doi:10.1093/emboj/18.20.5528. PMID 10523297. 
• "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.". Oncogene 18 (44): 6029–36. 1999. doi:10.1038/sj.onc.1202983. PMID 10557092. 
• "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.". Oncogene 19 (42): 4832–9. 2000. doi:10.1038/sj.onc.1203845. PMID 11039900. 
• "Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase.". DNA Seq. 11 (6): 527–33. 2002. doi:10.3109/10425170109041337. PMID 11696980. 
• "Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells.". Biochem. Biophys. Res. Commun. 289 (2): 491–8. 2002. doi:10.1006/bbrc.2001.5993. PMID 11716500. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.". Mol. Cancer Res. 1 (5): 376–84. 2003. PMID 12651910. 
• "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. 2003. doi:10.1038/sj.onc.1206406. PMID 12761501. 
• "Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.". Mol. Cell. Biol. 23 (16): 5556–71. 2003. doi:10.1128/MCB.23.16.5556-5571.2003. PMID 12897130. 
• "Role of Plk2 (Snk) in mouse development and cell proliferation.". Mol. Cell. Biol. 23 (19): 6936–43. 2003. doi:10.1128/MCB.23.19.6936-6943.2003. PMID 12972611. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.". J. Biol. Chem. 280 (50): 41619–27. 2006. doi:10.1074/jbc.M508397200. PMID 16203730. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma).". Biochem. Biophys. Res. Commun. 362 (1): 107–13. 2007. doi:10.1016/j.bbrc.2007.07.170. PMID 17706602. 
• "Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.". Cell Cycle 6 (20): 2571–8. 2007. doi:10.4161/cc.6.20.5079. PMID 17912033.