Biology:PLK3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.

Interactions

PLK3 has been shown to interact with:

• CDC25C,
• CHEK2, and
• P53.

Further reading

• "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. 1996. doi:10.1074/jbc.271.32.19402. PMID 8702627. 
• "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science 277 (5331): 1501–5. 1997. doi:10.1126/science.277.5331.1501. PMID 9278512. 
• "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions". J. Biol. Chem. 272 (45): 28646–51. 1997. doi:10.1074/jbc.272.45.28646. PMID 9353331. 
• "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. 1999. doi:10.1093/emboj/18.20.5528. PMID 10523297. 
• "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene 18 (44): 6029–36. 1999. doi:10.1038/sj.onc.1202983. PMID 10557092. 
• "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites". Genes Dev. 14 (3): 289–300. 2000. doi:10.1101/gad.14.3.289. PMID 10673501. 
• "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer 27 (3): 332–6. 2000. doi:10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K. PMID 10679924. 
• "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389–94. 2000. doi:10.1073/pnas.190030497. PMID 10973490. Bibcode: 2000PNAS...9710389M. 
• "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene 19 (42): 4832–9. 2000. doi:10.1038/sj.onc.1203845. PMID 11039900. 
• "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature 411 (6833): 102–7. 2001. doi:10.1038/35075107. PMID 11333986. Bibcode: 2001Natur.411..102B. 
• "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. 2001. doi:10.1074/jbc.M106050200. PMID 11551930. 
• "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene 20 (46): 6784–93. 2001. doi:10.1038/sj.onc.1204883. PMID 11709713. 
• "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain". J. Biol. Chem. 277 (22): 19389–95. 2002. doi:10.1074/jbc.M200822200. PMID 11901158. 
• "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase". Mol. Cell 9 (3): 515–25. 2002. doi:10.1016/S1097-2765(02)00473-2. PMID 11931760. 
• "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity". Mol. Cell. Biol. 22 (10): 3450–9. 2002. doi:10.1128/MCB.22.10.3450-3459.2002. PMID 11971976. 
• "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene 21 (43): 6633–40. 2002. doi:10.1038/sj.onc.1205850. PMID 12242661. 
• "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody". J. Biol. Chem. 278 (10): 8468–75. 2003. doi:10.1074/jbc.M211202200. PMID 12493754. 
• "Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2". Cell Cycle 1 (6): 424–9. 2003. doi:10.4161/cc.1.6.271. PMID 12548019. 
• "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation". Oncogene 23 (15): 2658–63. 2004. doi:10.1038/sj.onc.1207425. PMID 14968113.