Biology:PLXNB3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.[1][2]
Interactions
PLXNB3 has been shown to interact with ARHGEF11.[3][4]
Model organisms
Model organisms have been used in the study of PLXNB3 function. A conditional knockout mouse line called Plxnb3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]
| Characteristic | Phenotype |
|---|---|
| All data available at.[6][11]{ | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Insulin | Normal |
| Haematology 6 Weeks | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Abnormal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
| Influenza Challenge | Normal |
References
- ↑ "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. Oct 1999. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
- ↑ "Entrez Gene: PLXNB3 plexin B3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5365.
- ↑ "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry 277 (45): 43115–20. Nov 2002. doi:10.1074/jbc.M206005200. PMID 12183458.
- ↑ "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. Jul 2002. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 6.0 6.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=Plxnb3#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. Jul 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 11.0 11.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=Plxnb3&field_gene_construct_tid=All.
Further reading
- "The genomic organization of a human creatine transporter (CRTR) gene located in Xq28". Genomics 35 (2): 383–5. Jul 1996. doi:10.1006/geno.1996.0373. PMID 8661155.
- "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. Aug 1997. doi:10.1006/geno.1997.4822. PMID 9286695.
- "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (5): 337–45. Oct 1999. doi:10.1093/dnares/6.5.337. PMID 10574462.
- "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry 277 (45): 43115–20. Nov 2002. doi:10.1074/jbc.M206005200. PMID 12183458.
- "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene 23 (30): 5131–7. Jul 2004. doi:10.1038/sj.onc.1207650. PMID 15184888.
- "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Reports 5 (7): 710–4. Jul 2004. doi:10.1038/sj.embor.7400189. PMID 15218527.
- "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science 308 (5725): 1149–54. May 2005. doi:10.1126/science.1108625. PMID 15790807.
- "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience 6: 53. 2006. doi:10.1186/1471-2202-6-53. PMID 16122393.
- "Plexin B3 is genetically associated with verbal performance and white matter volume in human brain". Molecular Psychiatry 12 (2): 190–4, 115. Feb 2007. doi:10.1038/sj.mp.4001903. PMID 17033634.
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