Biology:POLE3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.[1][2][3]
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM][3]
Interactions
POLE3 has been shown to interact with SMARCA5.[2]
References
- ↑ "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem 275 (30): 23247–52. Aug 2000. doi:10.1074/jbc.M002548200. PMID 10801849.
- ↑ 2.0 2.1 "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J 19 (13): 3377–87. Oct 2000. doi:10.1093/emboj/19.13.3377. PMID 10880450.
- ↑ 3.0 3.1 "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54107.
Further reading
- "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Cloning and characterization of the histone-fold proteins YBL1 and YCL1.". Nucleic Acids Res. 28 (19): 3830–8. 2000. doi:10.1093/nar/28.19.3830. PMID 11000277.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.". Nucleic Acids Res. 31 (19): 5568–75. 2003. doi:10.1093/nar/gkg765. PMID 14500819.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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