Biology:PPIP5K2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene.

Function

Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.

HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

Further reading

• "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614. 
• "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding". Nat. Chem. Biol. 8 (1): 111–6. 2011. doi:10.1038/nchembio.733. PMID 22119861. 
• "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment". Biosci. Rep. 33 (2): e00022. 2013. doi:10.1042/BSR20120115. PMID 23240582. 
• "Identification of a functional nuclear translocation sequence in hPPIP5K2". BMC Cell Biol. 16: 17. 2015. doi:10.1186/s12860-015-0063-7. PMID 26084399. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.