Biology:PPP2R5A
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.[1]
Function
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.[2]
Interactions
PPP2R5A has been shown to interact with:
References
- ↑ "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry 270 (44): 26123–8. Nov 1995. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- ↑ "Entrez Gene: PPP2R5A protein phosphatase 2, regulatory subunit B', alpha isoform". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5525.
- ↑ "Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A". The Journal of Biological Chemistry 276 (29): 26875–82. Jul 2001. doi:10.1074/jbc.M100443200. PMID 11297546.
- ↑ "Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A". Journal of Immunology 168 (10): 5070–8. May 2002. doi:10.4049/jimmunol.168.10.5070. PMID 11994459.
- ↑ 5.0 5.1 5.2 "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. Jan 2009. doi:10.1074/mcp.M800266-MCP200. PMID 18782753.
- ↑ 6.0 6.1 "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. Sep 1996. doi:10.1074/jbc.271.36.22081. PMID 8703017.
- ↑ 7.0 7.1 "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal 369 (Pt 2): 387–98. Jan 2003. doi:10.1042/BJ20021244. PMID 12370081.
- ↑ 8.0 8.1 "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry 277 (23): 20750–5. Jun 2002. doi:10.1074/jbc.M202992200. PMID 11929880.
Further reading
- "The role of Vpr in HIV-1 pathogenesis". Current HIV Research 3 (1): 43–51. Jan 2005. doi:10.2174/1570162052772988. PMID 15638722.
- "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. 2006. doi:10.1186/1742-4690-2-11. PMID 15725353.
- "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. Mar 2005. doi:10.1038/sj.cr.7290279. PMID 15780175.
- "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. Apr 2005. PMID 15817944.
- "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal 317 (1): 187–94. Jul 1996. doi:10.1042/bj3170187. PMID 8694763.
- "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochemical and Biophysical Research Communications 224 (2): 289–96. Jul 1996. doi:10.1006/bbrc.1996.1023. PMID 8702385.
- "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. Sep 1996. doi:10.1074/jbc.271.36.22081. PMID 8703017.
- "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics 36 (1): 168–70. Aug 1996. doi:10.1006/geno.1996.0438. PMID 8812429.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2–3): 197–201. Jan 1997. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
- "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. Nov 1997. doi:10.1006/viro.1997.8873. PMID 9400615.
- "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". Journal of Virology 73 (1): 839–42. Jan 1999. doi:10.1128/JVI.73.1.839-842.1999. PMID 9847399.
- "Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A". Science 283 (5410): 2089–91. Mar 1999. doi:10.1126/science.283.5410.2089. PMID 10092233.
- "The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR". Molecular and Cellular Biology 20 (14): 5285–99. Jul 2000. doi:10.1128/MCB.20.14.5285-5299.2000. PMID 10866685.
- "Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity". Circulation Research 88 (11): E68–75. Jun 2001. doi:10.1161/hh1101.092677. PMID 11397791.
- "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. Sep 2001. doi:10.1006/viro.2001.1007. PMID 11531413.
- "ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A". The Journal of Biological Chemistry 276 (49): 45833–9. Dec 2001. doi:10.1074/jbc.M107149200. PMID 11585828.
- "Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A". European Journal of Biochemistry / FEBS 269 (2): 546–52. Jan 2002. doi:10.1046/j.0014-2956.2001.02680.x. PMID 11856313.
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