Biology:PRKCG

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

Interactions

PRKCG has been shown to interact with GRIA4.

See also

• Protein kinase C

Further reading

• "Glycogen synthase kinase-3: properties, functions, and regulation.". Chem. Rev. 101 (8): 2527–40. 2002. doi:10.1021/cr000110o. PMID 11749387. 
• "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.". Chem. Phys. Lipids 116 (1–2): 75–91. 2003. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536. 
• "Protein kinase C gamma (PKC gamma): function of neuron specific isotype". J. Biochem. 132 (5): 683–7. 2003. doi:10.1093/oxfordjournals.jbchem.a003274. PMID 12417016. 

External links

• GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14