Biology:PRSS3

Generic protein structure example

Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

Further reading

• "Nexin-1 inhibits the activity of human brain trypsin". Neuroscience 160 (1): 97–102. April 2009. doi:10.1016/j.neuroscience.2009.02.042. PMID 19249338. 
• "Nucleotide sequence of the human pancreatic trypsinogen III cDNA". Nucleic Acids Research 18 (6): 1631. March 1990. doi:10.1093/nar/18.6.1631. PMID 2326201. 
• "Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription". Proceedings of the National Academy of Sciences of the United States of America 108 (46): 18766–71. November 2011. doi:10.1073/pnas.1116273108. PMID 22042864. Bibcode: 2011PNAS..10818766H. 
• "The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin". The Journal of Biological Chemistry 285 (3): 1939–49. January 2010. doi:10.1074/jbc.M109.057216. PMID 19920152. 
• "Absence of mesotrypsinogen gene (PRSS3) copy number variations in patients with chronic pancreatitis". Pancreas 37 (2): 227–8. August 2008. doi:10.1097/MPA.0b013e3181654b6a. PMID 18665091. 
• "Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance". The Journal of Biological Chemistry 272 (16): 10573–8. April 1997. doi:10.1074/jbc.272.16.10573. PMID 9099703. 
• "Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia". The Journal of Biological Chemistry 282 (36): 26089–100. September 2007. doi:10.1074/jbc.M703840200. PMID 17623652. 
• "Structure of a serpin-protease complex shows inhibition by deformation". Nature 407 (6806): 923–6. October 2000. doi:10.1038/35038119. PMID 11057674. Bibcode: 2000Natur.407..923H. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.