Biology:Periodontal ligament stem cells

From HandWiki

Periodontal ligament stem cells or periodontal membrane stem cells are stem cells found near the periodontal ligament of the teeth. These cells have shown potential in the regeneration of not only the periodontal complex but also other dental and non-dental tissues.[1][2][3] They are involved in adult regeneration of the periodontal ligament, alveolar bone, and cementum. The cells are known to express STRO-1 and CD146 proteins.[4]

Periodontal ligament stem cells play a role as progenitor cells.[5] They are capable of generating into osteoblasts, cementoblasts, chondrocytes, and adipocytes.

References

  1. ↑ Seo, Byoung-Moo; Miura, Masako; Gronthos, Stan; Mark Bartold, Peter; Batouli, Sara; Brahim, Jaime; Young, Marian; Gehron Robey, Pamela et al. (July 2004). "Investigation of multipotent postnatal stem cells from human periodontal ligament" (in en). The Lancet 364 (9429): 149–155. doi:10.1016/S0140-6736(04)16627-0. PMID 15246727. https://linkinghub.elsevier.com/retrieve/pii/S0140673604166270. 
  2. ↑ Yang, Y.; Alves, T.; Miao, M.Z.; Wu, Y.C.; Li, G.; Lou, J.; Hasturk, H.; Van Dyke, T.E. et al. (January 2024). "Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells" (in en). Journal of Dental Research 103 (1): 71–80. doi:10.1177/00220345231205283. ISSN 0022-0345. PMID 37982164. 
  3. ↑ Queiroz, Aline; Albuquerque-Souza, Emmanuel; Gasparoni, Leticia Miquelitto; França, Bruno Nunes de; Pelissari, Cibele; Trierveiler, Marília; Holzhausen, Marinella (2021-06-26). "Therapeutic potential of periodontal ligament stem cells". World Journal of Stem Cells 13 (6): 605–618. doi:10.4252/wjsc.v13.i6.605. ISSN 1948-0210. PMID 34249230. 
  4. ↑ Alves, Tomaz; Gasparoni, Letícia M.; Balzarini, Danilo; Albuquerque-Souza, Emmanuel; de Oliveira, Victhor; Rovai, Emanuel S.; da Silva, Jose; Huamán-Mendoza, Aldrin et al. (2022-09-18). "Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PAR1) in vivo" (in en). Scientific Reports 12 (1). doi:10.1038/s41598-022-19520-x. ISSN 2045-2322. PMID 36117187. 
  5. ↑ Han, J; Menicanin, D; Gronthos, S; Bartold, PM (2013-09-23). "Stem cells, tissue engineering and periodontal regeneration". Australian Dental Journal 59 (s1): 117–130. doi:10.1111/adj.12100. ISSN 0045-0421. PMID 24111843. 




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