Biology:Permease of phosphotransferase system
| Phosphotransferase permease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | PTS | ||||||||
| Pfam | PF03611 | ||||||||
| InterPro | IPR004703 | ||||||||
| TCDB | 4.A.7 | ||||||||
| OPM superfamily | 426 | ||||||||
| OPM protein | 5zov | ||||||||
| |||||||||
Permease of phosphotransferase system (or PTS-AG superfamily according to TCDB) is a superfamily of phosphotransferase enzymes that facilitate the transport of L-ascorbate (A) and galactitol (G). Classification has been established through phylogenic analysis and bioinformatics.[1][2]
The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I (I), HPr, Enzyme IIA (IIA), and Enzyme IIB (IIB)) as well as the integral membrane sugar permease (IIC).[3][4] The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the (1) Glucose (Glc),(2) Mannose (Man), (3) Ascorbate-Galactitol (Asc-Gat) and (4) Dihydroxyacetone (Dha) superfamilies.
The four families that make up the PTS-GFL superfamily include:
See also
- Phosphotransferases system
References
- ↑ "Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments". Journal of Molecular Microbiology and Biotechnology 21 (3–4): 83–96. 2012-01-01. doi:10.1159/000334611. PMID 22286036.
- ↑ "Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system". Journal of Molecular Microbiology and Biotechnology 11 (6): 345–60. 2006-01-01. doi:10.1159/000095636. PMID 17114898.
- ↑ "Crystal structure of a phosphorylation-coupled vitamin C transporter". Nature Structural & Molecular Biology 22 (3): 238–41. March 2015. doi:10.1038/nsmb.2975. PMID 25686089.
- ↑ "Inward-facing conformation of l-ascorbate transporter suggests an elevator mechanism". Cell Discovery 4: 35. 2018. doi:10.1038/s41421-018-0037-y. PMID 30038796.
Further reading
- "TCDB - PTS-AG Superfamily". www.tcdb.org.
- "Phylogeny as a guide to structure and function of membrane transport proteins". Molecular Membrane Biology 21 (3): 171–81. 2004. doi:10.1080/09687680410001720830. PMID 15204625.
 |  |
