Chemistry:Galactitol
From HandWiki
Galactitol (dulcitol) is a sugar alcohol, the reduction product of galactose.[1] It has a slightly sweet taste.[1] In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens of the eye leading to cataracts.[2]
Galactitol is produced from galactose in a reaction catalyzed by aldose reductase.[3]
The other common galactose metabolism defect is a defect in galactose-1-phosphate uridylyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. This disorder leads to cataracts caused by galactitol buildup.[4]
References
- ↑ 1.0 1.1 "Galactitol - Compound Summary". National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/11850.
- ↑ Roth, KS (September 10, 2007). "Galactokinase Deficiency". eMedicine. WebMD. http://www.emedicine.com/ped/TOPIC815.HTM.
- ↑ Narayanan, S. (1993-03-01). "Aldose reductase and its inhibition in the control of diabetic complications" (in en). Annals of Clinical & Laboratory Science 23 (2): 148–158. ISSN 0091-7370. PMID 8457142. http://www.annclinlabsci.org/content/23/2/148.
- ↑ Palmieri, Michael; Mazur, Alice; Berry, Gerard T.; Ning, Cong; Wehrli, Suzanne; Yager, Claire; Reynolds, Robert; Singh, Rani et al. (1999-10-01). "Urine and plasma galactitol in patients with galactose-1-phosphate uridyltransferase deficiency galactosemia". Metabolism 48 (10): 1294–1302. doi:10.1016/S0026-0495(99)90271-8. ISSN 0026-0495. https://www.sciencedirect.com/science/article/pii/S0026049599902718.
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