Biology:Phorbol-12-myristate-13-acetate-induced protein 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[1][2][3]
Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[4] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.
Interactions
Noxa has been shown to interact with:
See also
- Apoptosis
- Apoptosome
- Bcl-2
- Bcl-2-associated X protein (BAX)
- BH3 interacting domain death agonist (BID)
- Caspases
- Cytochrome c
- Mitochondrion
- p53 upregulated modulator of apoptosis (PUMA)
- 12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)
References
- ↑ "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol 64 (10): 4632–9. October 1990. doi:10.1128/JVI.64.10.4632-4639.1990. PMID 2398525.
- ↑ "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene 22 (30): 4675–8. July 2003. doi:10.1038/sj.onc.1206655. PMID 12879012.
- ↑ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5366.
- ↑ "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288 (5468): 1053–1058. May 2000. doi:10.1126/science.288.5468.1053. PMID 10807576. Bibcode: 2000Sci...288.1053O.
- ↑ 5.0 5.1 5.2 "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. February 2005. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
- ↑ 6.0 6.1 "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288 (5468): 1053–8. May 2000. doi:10.1126/science.288.5468.1053. PMID 10807576. Bibcode: 2000Sci...288.1053O.
- ↑ "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11): 1294–305. June 2005. doi:10.1101/gad.1304105. PMID 15901672.
- ↑ Heckmeier, Philipp J.; Ruf, Jeannette; Janković, Brankica G.; Hamm, Peter (7 March 2023). "MCL-1 promiscuity and the structural resilience of its binding partners". The Journal of Chemical Physics 158 (9). doi:10.1063/5.0137239. PMID 36889945. Bibcode: 2023JChPh.158i5101H.
Further reading
- "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.". Science 288 (5468): 1053–8. 2000. doi:10.1126/science.288.5468.1053. PMID 10807576. Bibcode: 2000Sci...288.1053O.
- "The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.". J. Biol. Chem. 278 (48): 48292–9. 2004. doi:10.1074/jbc.M308785200. PMID 14500711.
- "BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha.". J. Exp. Med. 199 (1): 113–24. 2004. doi:10.1084/jem.20030613. PMID 14699081.
- "BOK and NOXA are essential mediators of p53-dependent apoptosis.". J. Biol. Chem. 279 (27): 28367–74. 2004. doi:10.1074/jbc.M313526200. PMID 15102863.
- "p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.". Mol. Cancer Ther. 3 (8): 895–902. 2005. doi:10.1158/1535-7163.895.3.8. PMID 15299072.
- "E1A activates transcription of p73 and Noxa to induce apoptosis.". J. Biol. Chem. 280 (7): 5945–59. 2005. doi:10.1074/jbc.M406661200. PMID 15572378. https://www.openaccessrepository.it/record/95333/files/fulltext.pdf.
- "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. 2005. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
- "Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.". J. Biol. Chem. 280 (16): 15561–8. 2005. doi:10.1074/jbc.M412630200. PMID 15705586.
- "Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes.". Oncogene 24 (28): 4559–71. 2005. doi:10.1038/sj.onc.1208652. PMID 15856024.
- "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.". Genes Dev. 19 (11): 1294–305. 2005. doi:10.1101/gad.1304105. PMID 15901672.
- "The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.". Immunity 24 (6): 703–16. 2006. doi:10.1016/j.immuni.2006.03.018. PMID 16782027.
- "FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells.". Cell Death Differ. 14 (3): 534–47. 2007. doi:10.1038/sj.cdd.4402017. PMID 16888645.
- "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.". J. Biol. Chem. 281 (42): 31440–7. 2006. doi:10.1074/jbc.M604356200. PMID 16928686.
- "Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.". Blood 109 (4): 1660–8. 2007. doi:10.1182/blood-2006-05-021683. PMID 17038534.
- "Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.". Apoptosis 12 (3): 613–22. 2007. doi:10.1007/s10495-006-0020-1. PMID 17216584.
- "NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.". Proc Natl Acad Sci USA 119 (9). 2022. doi:10.1073/pnas.2105691119. PMID 35197278. Bibcode: 2022PNAS..11905691D.
External links
- NOXA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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