Biology:Phosphoserine transaminase
From HandWiki
| Phosphoserine transaminase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.6.1.52 | ||||||||
| CAS number | 9030-90-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phosphoserine transaminase (EC 2.6.1.52, PSAT, phosphoserine aminotransferase, 3-phosphoserine aminotransferase, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, 3-O-phospho-L-serine:2-oxoglutarate aminotransferase, SerC, PdxC, 3PHP transaminase) is an enzyme with systematic name O-phospho-L-serine:2-oxoglutarate aminotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) O-phospho-L-serine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] 3-phosphonooxypyruvate + L-glutamate
- (2) 4-phosphonooxy-L-threonine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate
This enzyme is a pyridoxal-phosphate protein.
See also
References
- ↑ "Studies on phosphoserine aminotransferase of sheep brain". The Journal of Biological Chemistry 242 (9): 2283–7. May 1967. PMID 6022873.
- ↑ "The pathway and control of serine biosynthesis in Escherichia coli". The Journal of Biological Chemistry 238: 3934–44. December 1963. PMID 14086727.
- ↑ "A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria". Journal of Bacteriology 178 (1): 232–9. January 1996. PMID 8550422.
- ↑ "4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis". FEBS Letters 390 (2): 179–82. July 1996. doi:10.1016/0014-5793(96)00652-7. PMID 8706854.
- ↑ "4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12". FEMS Microbiology Letters 135 (2-3): 275–80. January 1996. doi:10.1111/j.1574-6968.1996.tb08001.x. PMID 8595869.
External links
- Phosphoserine+transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
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