Biology:Phosphoserine transaminase

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Phosphoserine transaminase
Identifiers
EC number2.6.1.52
CAS number9030-90-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Phosphoserine transaminase (EC 2.6.1.52, PSAT, phosphoserine aminotransferase, 3-phosphoserine aminotransferase, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, 3-O-phospho-L-serine:2-oxoglutarate aminotransferase, SerC, PdxC, 3PHP transaminase) is an enzyme with systematic name O-phospho-L-serine:2-oxoglutarate aminotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) O-phospho-L-serine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] 3-phosphonooxypyruvate + L-glutamate
(2) 4-phosphonooxy-L-threonine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

See also

References

  1. "Studies on phosphoserine aminotransferase of sheep brain". The Journal of Biological Chemistry 242 (9): 2283–7. May 1967. PMID 6022873. 
  2. "The pathway and control of serine biosynthesis in Escherichia coli". The Journal of Biological Chemistry 238: 3934–44. December 1963. PMID 14086727. 
  3. "A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria". Journal of Bacteriology 178 (1): 232–9. January 1996. PMID 8550422. 
  4. "4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis". FEBS Letters 390 (2): 179–82. July 1996. doi:10.1016/0014-5793(96)00652-7. PMID 8706854. 
  5. "4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12". FEMS Microbiology Letters 135 (2-3): 275–80. January 1996. doi:10.1111/j.1574-6968.1996.tb08001.x. PMID 8595869. 

External links