Biology:Polymerase basic protein 2
From HandWiki
| Identifiers | |||||||
|---|---|---|---|---|---|---|---|
| Organism | |||||||
| Symbol | PB2 | ||||||
| Entrez | 956536 | ||||||
| PDB | 2VQZ (ECOD) | ||||||
| RefSeq (Prot) | NP_040987.1 | ||||||
| UniProt | P21428 | ||||||
| Other data | |||||||
| Chromosome | Genome: 0 - 0 Mb | ||||||
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Influenza virus polymerase basic protein 2 (PB2) is a core subunit of the viral RNA-dependent RNA polymerase complex that is essential for both transcription and replication of the negative-strand RNA genome.[1] PB2 binds capped host pre-mRNAs and participates in the “cap snatching” process that generates primers for viral mRNA synthesis.[2] PB2 also acts as a key determinant of host range and pathogenicity in different influenza A strains, including through amino-acid substitutions such as the lysine at position 627.[3] In addition, PB2 is imported into the mitochondrial matrix, where it may influence viral replication and host–virus interactions.[4]
References
- ↑ "Polymerase basic protein 2". UniProt. https://www.uniprot.org/uniprotkb/P21428/entry.
- ↑ "The biology of influenza viruses". Vaccine 26 (Suppl 4): D49–D53. September 2008. doi:10.1016/j.vaccine.2008.07.039. PMID 19230160.
- ↑ "Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue". The Journal of Biological Chemistry 284 (11): 6855–6860. March 2009. doi:10.1074/jbc.C800224200. PMID 19144639.
- ↑ "The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix". Journal of Virology 90 (19): 8729–8738. October 2016. doi:10.1128/JVI.01384-16. PMID 27440905.
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