Biology:Promegakaryocyte
A promegakaryocyte is a precursor cell for a megakaryocyte. It arises from a megakaryoblast, into a promegakaryocyte and then into a megakaryocyte, which will eventually break off and become a platelet.[1]
The developmental stages of the megakaryocyte are: CFU-Me (pluripotential hemopoietic stem cell or hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte.
When the megakaryoblast matures into the promegakaryocyte, it undergoes endoreduplication[2] and forms a promegakaryocyte which has multiple nuclei, azurophilic granules, and a basophilic cytoplasm.[3] The promegakaryocyte has rotary motion, but no forward migration.[4]
Promegakaryocytes and other precursor cells to megakaryocytes arise from pluripotential hematopoietic progenitors.[5] The megakaryoblast is then produced, followed by the promegakaryocyte, the granular megakaryocyte, and then the mature megakaryocyte.[6] When it is in its promegakaryocyte stage, it is considered an undifferentiated cell.[7]
Megakaryocyte pieces will eventually break off and begin circulating the body as platelets. Platelets are very important because of their role in blood clotting, immune response, and the formation of new blood vessels.[8]
References
- ↑ Anatomy & physiology. Houston, Texas. 2013. ISBN 978-1-947172-04-3. OCLC 898069394. https://www.worldcat.org/oclc/898069394.
- ↑ Textbook of Human Physiology for Dental Students. Elsevier India. November 20, 2009. p. 141. ISBN 978-8131205921.
- ↑ Microscopic Haematology: A Practical Guide for the Laboratory (2nd ed.). CRC Press. December 19, 2002. p. 95. ISBN 1841842338.
- ↑ "On the function of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombocytopenic Purpura and in Normal Adult". Acta Medicinae Okayama 10 (2): 57–61. January 31, 1956. http://ousar.lib.okayama-u.ac.jp/en/30294. Retrieved July 21, 2017.
- ↑ Platelets (2nd ed.). Amsterdam: Academic Press/Elsevier. 2007. ISBN 978-0-12-369367-9. OCLC 162572838. https://www.worldcat.org/oclc/162572838.
- ↑ "Platelets", Clinical Methods: The History, Physical, and Laboratory Examinations (Boston: Butterworths), 1990, ISBN 978-0-409-90077-4, PMID 21250105, http://www.ncbi.nlm.nih.gov/books/NBK262/, retrieved 2021-10-13
- ↑ "Regulation of bone metabolism by megakaryocytes in a paracrine manner". Scientific Reports 10 (1): 2277. February 2020. doi:10.1038/s41598-020-59250-6. PMID 32042021. Bibcode: 2020NatSR..10.2277L.
- ↑ "Megakaryocyte- and megakaryocyte precursor-related gene therapies". Blood 127 (10): 1260–1268. March 2016. doi:10.1182/blood-2015-07-607937. PMID 26787735.
External links
- "Marrow aspirate, 10x. Promegakaryocyte" at ttuhsc.edu
- "Megakaryocytes: Promegakaryocyte" at bloodline.net
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