Biology:CFU-GM
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| CFU-GM | |
|---|---|
 Lineage. Captions in Polish, but "GMP" visible near bottom center. | |
| Details | |
| Gives rise to | Monoblasts and myeloblasts |
| Location | Bone marrow |
| Function | colony forming unit |
| Anatomical terms of microanatomy | |
CFU-GM, also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM.
The "GM" stands for "granulocyte, monocyte".[1]
It is the precursor for monoblasts and myeloblasts.
Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
Granulocytes
There is some controversy over which granulocytes derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".[2]
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".[3]
See also
References
- ↑ "Hem I WBC Morphology and Physiology". http://www.clt.astate.edu/wwilliam/hem_i_wbc_morphology_and_physiology.htm.
- ↑ Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. pp. 107. ISBN 0-07-144159-X.
- ↑ Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. pp. 1563. ISBN 0-8385-8285-0.
External links
- CFU-GM at the US National Library of Medicine Medical Subject Headings (MeSH)
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