Biology:Proteoform
From HandWiki
Short description: Different forms of a protein
Proteoforms are the different forms of a protein produced from the genome with a variety of sequence variations, splice isoforms, and post-translational modifications.[1][2] Proteoform captures the disparate sources of biological variation which alter primary sequence and composition at the whole-protein level. Protein characterization at the proteoform level has a crucial importance to fully understand biological processes since specific proteoforms can carry particular biological functions.[3] The proteoforms estimation in human can be in millions for around 20,000 proteins.[4]
References
- ↑ "Proteoforms as the next proteomics currency". Science 359 (6380): 1106–1107. March 2018. doi:10.1126/science.aat1884. PMID 29590032. Bibcode: 2018Sci...359.1106S.
- ↑ "Proteoform: a single term describing protein complexity". Nature Methods 10 (3): 186–7. March 2013. doi:10.1038/nmeth.2369. PMID 23443629.
- ↑ "ProteoCombiner: integrating bottom-up with top-down proteomics data for improved proteoform assessment". Bioinformatics: btaa958. November 2020. doi:10.1093/bioinformatics/btaa958. PMID 33165572. https://hal-pasteur.archives-ouvertes.fr/pasteur-03014113/file/btaa958.pdf.
- ↑ "How many human proteoforms are there?". Nature Chemical Biology 14 (3): 206–214. February 2018. doi:10.1038/nchembio.2576. PMID 29443976.
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