Biology:Pyruvate dehydrogenase (NADP+)
From HandWiki
| Pyruvate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.51 | ||||||||
| CAS number | 93389-35-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Pyruvate dehydrogenase (NADP+) EC 1.2.1.51 is an enzyme that should not be confused with Pyruvate dehydrogenase (acetyltransferase) EC 1.2.4.1.[1][2]
It catalyzes the following reaction:
- Pyruvate + Coenzyme A + NADP+ ⇒ acetyl-CoA + NADPH + H+ + CO2
References
- ↑ "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". Journal of Biochemistry 96 (3): 931–4. September 1984. doi:10.1093/oxfordjournals.jbchem.a134913. PMID 6438078.
- ↑ "Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis". The Journal of Biological Chemistry 262 (19): 9130–5. July 1987. PMID 3110154.
Further reading
- "Localization of pyruvate:NADP+ oxidoreductase in sporozoites of Cryptosporidium parvum". The Journal of Eukaryotic Microbiology 53 (4): 225–31. 2006. doi:10.1111/j.1550-7408.2006.00099.x. PMID 16872290.
- "The physiological role of oxygen-sensitive pyruvate dehydrogenase in mitochondrial fatty acid synthesis in Euglena gracilis". Archives of Biochemistry and Biophysics 237 (2): 423–9. March 1985. doi:10.1016/0003-9861(85)90295-4. PMID 3919646.
- "Pyruvate:NADP+ oxidoreductase from Euglena gracilis: the kinetic properties of the enzyme". Archives of Biochemistry and Biophysics 274 (2): 434–42. November 1989. doi:10.1016/0003-9861(89)90456-6. PMID 2508561.
- "Pyruvate:NADP+ oxidoreductase from Euglena gracilis: mechanism of O2-inactivation of the enzyme and its stability in the aerobe". Archives of Biochemistry and Biophysics 280 (2): 292–8. August 1990. doi:10.1016/0003-9861(90)90332-S. PMID 2114824.
- "Pyruvate:NADP+ oxidoreductase from Euglena gracilis: limited proteolysis of the enzyme with trypsin". Archives of Biochemistry and Biophysics 286 (1): 270–6. April 1991. doi:10.1016/0003-9861(91)90040-P. PMID 1910287.
- Lochmeyer, C.; Fuchs, G. (1990). "NADP+-specific 2-oxoglutarate dehydrogenase in denitrifying Pseudomonas species". Arch. Microbiol. 153 (3): 226–229. doi:10.1007/BF00249072.
- "The origin of pyruvate: NADP+ oxidoreductase in mitochondria of Euglena gracilis". FEBS Letters 479 (3): 155–6. August 2000. doi:10.1016/S0014-5793(00)01882-2. PMID 11023353.
- "Pyruvate:NADP+ oxidoreductase is stabilized by its cofactor, thiamin pyrophosphate, in mitochondria of Euglena gracilis". Archives of Biochemistry and Biophysics 411 (2): 183–8. March 2003. doi:10.1016/S0003-9861(02)00749-X. PMID 12623066.
- "Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42". Journal of Bioscience and Bioengineering 108 (5): 385–90. November 2009. doi:10.1016/j.jbiosc.2009.05.008. PMID 19804861.
External links
- EC 1.2.1.51 IUBMB Enzyme Nomenclature at chem.qmul.ac.uk
- EC 1.2.1.51 - pyruvate dehydrogenase (NADP+) at Brenda-enzymes.org
- ENZYME entry: EC 1.2.1.51 at Enzyme.expasy.org
 |  |
