Biology:RABAC1
From HandWiki
RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.[1][2][3] It is highly conserved in eukaryotes.[1] The protein is localized to Golgi[4] and late endosomes,[5] where it plays a role in vesicular trafficking, lipid transport and cell migration.[6]
Interactions
RABAC1 has been shown to interact with numerous prenylated members of the Rab GTPase family[1][7][8] and VAMP2.[8]
References
- ↑ 1.0 1.1 1.2 "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications 258 (3): 657–62. May 1999. doi:10.1006/bbrc.1999.0651. PMID 10329441. Bibcode: 1999BBRC..258..657B.
- ↑ "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". The Journal of Biological Chemistry 275 (24): 18511–9. Jun 2000. doi:10.1074/jbc.M909309199. PMID 10751420.
- ↑ "Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10567.
- ↑ "PRA isoforms are targeted to distinct membrane compartments". The Journal of Biological Chemistry 276 (9): 6225–33. Mar 2001. doi:10.1074/jbc.M009073200. PMID 11096102.
- ↑ "Yip3 catalyses the dissociation of endosomal Rab-GDI complexes". Nature 425 (6960): 856–9. Oct 2003. doi:10.1038/nature02057. PMID 14574414. Bibcode: 2003Natur.425..856S.
- ↑ "Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration". Molecular & Cellular Proteomics 10 (3): M900641–MCP200. Mar 2011. doi:10.1074/mcp.M900641-MCP200. PMID 20592422.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ 8.0 8.1 "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry 272 (43): 26991–8. Oct 1997. doi:10.1074/jbc.272.43.26991. PMID 9341137.
Further reading
- "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry 272 (43): 26991–8. Oct 1997. doi:10.1074/jbc.272.43.26991. PMID 9341137.
- "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron 25 (1): 203–14. Jan 2000. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
- "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". The Journal of Biological Chemistry 276 (30): 28219–25. Jul 2001. doi:10.1074/jbc.M101763200. PMID 11335720.
- "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochemical and Biophysical Research Communications 286 (4): 815–9. Aug 2001. doi:10.1006/bbrc.2001.5466. PMID 11520070. Bibcode: 2001BBRC..286..815B.
- "Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor". Journal of Virology 76 (1): 327–37. Jan 2002. doi:10.1128/JVI.76.1.327-337.2002. PMID 11739697.
- "PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation". The Journal of General Virology 86 (Pt 6): 1785–90. Jun 2005. doi:10.1099/vir.0.80873-0. PMID 15914857.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2)". Gene 371 (1): 154–65. Apr 2006. doi:10.1016/j.gene.2005.12.009. PMID 16481131.
- "PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1". The EMBO Journal 25 (17): 4120–30. Sep 2006. doi:10.1038/sj.emboj.7601282. PMID 16917502.
- "Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin". Biochemical and Biophysical Research Communications 349 (1): 200–8. Oct 2006. doi:10.1016/j.bbrc.2006.08.026. PMID 16930546. Bibcode: 2006BBRC..349..200K.
- "A role for prenylated rab acceptor 1 in vertebrate photoreceptor development". BMC Neuroscience 13. 2012. doi:10.1186/1471-2202-13-152. PMID 23241222.
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