Biology:REPS2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.[1][2][3]
Function
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
Interactions
REPS2 has been shown to interact with EPN1,[4] EPS15[5] and RALBP1.[1]
References
- ↑ 1.0 1.1 "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J Biol Chem 273 (2): 814–21. Feb 1998. doi:10.1074/jbc.273.2.814. PMID 9422736.
- ↑ "Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)". FEBS Lett 442 (2–3): 138–42. Feb 1999. doi:10.1016/S0014-5793(98)01644-5. PMID 9928989. Bibcode: 1999FEBSL.442..138K.
- ↑ 3.0 3.1 "Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9185.
- ↑ "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene 18 (43): 5915–22. Oct 1999. doi:10.1038/sj.onc.1202974. PMID 10557078.
- ↑ "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. Jul 1999. doi:10.1093/emboj/18.13.3629. PMID 10393179.
Further reading
- "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. 1999. doi:10.1093/emboj/18.13.3629. PMID 10393179.
- "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene 18 (43): 5915–22. 1999. doi:10.1038/sj.onc.1202974. PMID 10557078.
- "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. 2002. doi:10.1074/jbc.M112472200. PMID 11882656.
- "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". J. Biol. Chem. 277 (41): 38618–26. 2002. doi:10.1074/jbc.M203453200. PMID 12149250.
- "REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells". Oncogene 22 (19): 2920–5. 2003. doi:10.1038/sj.onc.1206397. PMID 12771942.
- "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. 2003. doi:10.1074/jbc.M302191200. PMID 12775724.
- "Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells". Oncogene 23 (33): 5607–15. 2004. doi:10.1038/sj.onc.1207750. PMID 15184881. https://repub.eur.nl/pub/73476/1207750a.pdf.
- "EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2". Int. J. Cancer 113 (4): 561–7. 2005. doi:10.1002/ijc.20612. PMID 15455380.
- "POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis". Biochem. Biophys. Res. Commun. 328 (4): 1003–9. 2005. doi:10.1016/j.bbrc.2005.01.055. PMID 15707977. Bibcode: 2005BBRC..328.1003Y.
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