Biology:RNF11

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[1][2][3]

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[3]

See also

Interactions

RNF11 has been shown to interact with RIPK1[4] and STAMBP.[5]

References

  1. "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta 1489 (2–3): 421–7. December 1999. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045. 
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. August 2000. doi:10.1101/gr.10.5.703. PMID 10810093. 
  3. 3.0 3.1 "Entrez Gene: RNF11 ring finger protein 11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26994. 
  4. "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. March 2009. doi:10.1038/emboj.2008.285. PMID 19131965. 
  5. "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. March 2004. doi:10.1038/sj.onc.1207319. PMID 14755250. 

Further reading

External links