Biology:RNF11
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[1][2][3]
Function
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[3]
See also
Interactions
RNF11 has been shown to interact with RIPK1[4] and STAMBP.[5]
References
- ↑ "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta 1489 (2–3): 421–7. December 1999. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
- ↑ "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. August 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- ↑ 3.0 3.1 "Entrez Gene: RNF11 ring finger protein 11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26994.
- ↑ "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. March 2009. doi:10.1038/emboj.2008.285. PMID 19131965.
- ↑ "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. March 2004. doi:10.1038/sj.onc.1207319. PMID 14755250.
Further reading
- "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia 8 (8): 689–95. 2006. doi:10.1593/neo.06469. PMID 16925951.
- "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. 2000. doi:10.1042/0264-6021:3510557. PMID 11042109.
- "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. 2002. doi:10.1016/S0002-9440(10)64176-4. PMID 12107109.
- "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta 1639 (2): 104–12. 2003. doi:10.1016/j.bbadis.2003.07.001. PMID 14559117.
- "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer 89 (8): 1538–44. 2003. doi:10.1038/sj.bjc.6601301. PMID 14562029.
- "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. 2004. doi:10.1038/sj.onc.1207319. PMID 14755250.
- "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. 2005. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. 2007. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.
External links
- RNF11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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