Biology:RNF12
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[1][2]
Function
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[2] Functions in female mice as a regulator of X chromosome inactivation .
Interactions
RNF12 has been shown to interact with Estrogen receptor alpha.[3]
References
- ↑ "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. Nov 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- ↑ 2.0 2.1 "Entrez Gene: RNF12 ring finger protein 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51132.
- ↑ "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. 69 (1): 128–36. Jan 2009. doi:10.1158/0008-5472.CAN-08-1630. PMID 19117995.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions". Development 130 (17): 4161–75. 2003. doi:10.1242/dev.00621. PMID 12874135.
- "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature 416 (6876): 99–103. 2002. doi:10.1038/416099a. PMID 11882901. Bibcode: 2002Natur.416...99O.
- "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors". Genomics 69 (1): 120–30. 2000. doi:10.1006/geno.2000.6311. PMID 11013082.
- "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. 1999. doi:10.1038/11970. PMID 10431247.
- "Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice". Nature 467 (7318): 977–81. 2010. doi:10.1038/nature09457. PMID 20962847. Bibcode: 2010Natur.467..977S.
- "Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling". Mol Biol Cell 24 (19): 3085–96. 2013. doi:10.1091/mbc.E13-05-0239. PMID 23904271.
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