Biology:RNF139
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.[1][2]
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].[2]
References
- ↑ "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A 95 (16): 9572–7. Sep 1998. doi:10.1073/pnas.95.16.9572. PMID 9689122. Bibcode: 1998PNAS...95.9572G.
- ↑ 2.0 2.1 "Entrez Gene: RNF139 ring finger protein 139". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11236.
Further reading
- "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.". Genes Chromosomes Cancer 46 (9): 805–12. 2007. doi:10.1002/gcc.20466. PMID 17539022.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.". Oncogene 26 (16): 2263–71. 2007. doi:10.1038/sj.onc.1210017. PMID 17016439.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.". Oncogene 21 (22): 3507–16. 2002. doi:10.1038/sj.onc.1205437. PMID 12032852.
- "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. 1999. doi:10.1073/pnas.96.20.11364. PMID 10500182. Bibcode: 1999PNAS...9611364L.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
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