Biology:RPS6KA4
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Short description: Enzyme found in humans
 Generic protein structure example |
Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[1][2][3]
Function
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]
Interactions
RPS6KA4 has been shown to interact with MAPK14.[1]
References
- ↑ 1.0 1.1 "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem 273 (45): 29661–29671. Dec 1998. doi:10.1074/jbc.273.45.29661. PMID 9792677.
- ↑ "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J 17 (15): 4426–4441. Sep 1998. doi:10.1093/emboj/17.15.4426. PMID 9687510.
- ↑ 3.0 3.1 "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986.
Further reading
- "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science 273 (5277): 959–963. 1996. doi:10.1126/science.273.5277.959. PMID 8688081. Bibcode: 1996Sci...273..959X.
- "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–32379. 1999. doi:10.1074/jbc.273.49.32377. PMID 9829964.
- "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor". J. Biol. Chem. 275 (31): 23549–23558. 2000. doi:10.1074/jbc.M002586200. PMID 10806207.
- Tomás-Zuber M; Mary JL; Lamour F et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)". J. Biol. Chem. 276 (8): 5892–5899. doi:10.1074/jbc.M005822200. PMID 11035004.
- Gudi T; Casteel DE; Vinson C et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene 19 (54): 6324–6333. doi:10.1038/sj.onc.1204007. PMID 11175347.
- Prymakowska-Bosak M; Misteli T; Herrera JE et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–5178. doi:10.1128/MCB.21.15.5169-5178.2001. PMID 11438671.
- Wiggin GR; Soloaga A; Foster JM et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts". Mol. Cell. Biol. 22 (8): 2871–2881. doi:10.1128/MCB.22.8.2871-2881.2002. PMID 11909979.
- Soloaga A; Thomson S; Wiggin GR et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. PMID 12773393.
- Wissing J; Jänsch L; Nimtz M et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics 6 (3): 537–547. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
- Gesser B; Johansen C; Rasmussen MK et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect". J. Invest. Dermatol. 127 (9): 2129–2137. doi:10.1038/sj.jid.5700859. PMID 17495961.
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