Biology:Rixosome
From HandWiki
The rixosome is a protein complex involved in RNA degradation, ribosomal RNA (rRNA) processing, and ribosome biogenesis. It was named after the S. cerevisiae gene RIX1.[1][2] The rixosome is associated with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain of PRC1 based on mutational analysis. The co-localization of the rixosome and PRC complex suggest a role in the rixosomal degradation of nascent RNA to contribute to the silencing of many Polycomb targets in human cells.[3] Regulation of the interaction with the PRC1 complex is mediated by SENP3 which deSUMOylates several rixosome subunits.[4]
Components
Rixosome complex contains the following components:
References
- ↑ "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell 23 (4): 716–728. February 2012. doi:10.1091/mbc.E11-06-0530. PMID 22190735.
- ↑ "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife 9. June 2020. doi:10.7554/eLife.54341. PMID 32491985.
- ↑ "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature 604 (7904): 167–174. April 2022. doi:10.1038/s41586-022-04598-0. PMID 35355014. Bibcode: 2022Natur.604..167Z.
- ↑ Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J (2023). "SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.". Cell Rep 42 (4). doi:10.1016/j.celrep.2023.112339. PMID 37014752. PMC 10777863. https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(23)00350-9.
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