Biology:RnaG
From HandWiki
| RnaG sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of RnaG small RNA | |
| Identifiers | |
| Rfam | RF02550 |
| Other data | |
| Domain(s) | Bacteria |
| SO | 0000077,0000370 |
| PDB structures | PDBe |
RnaG is a small regulatory non-coding RNA encoded by the virulence plasmid of Shigella flexneri, a Gram-negative pathogenic bacterium that causes human bacillary dysentery. It is a first regulatory RNA characterised in S. flexneri. The RNA is 450 nucleotides long (which makes it one of the largest regulatory sRNAs) and it contains a region with specific secondary structure that interacts with icsA (virG) mRNA and forms a transcription terminator. Acting as antisense, RnaG is transcribed from the complementary strand of its target, icsA mRNA.[1] The activity of the incA protein is crucial for spreading of the bacterial pathogen in the host cells.[2]
References
- ↑ "A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri". Nucleic Acids Research 38 (10): 3362–3375. June 2010. doi:10.1093/nar/gkq025. PMID 20129941.
- ↑ "Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin". Proceedings of the National Academy of Sciences of the United States of America 86 (10): 3867–3871. May 1989. doi:10.1073/pnas.86.10.3867. PMID 2542950.
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