Biology:rs6311
| SNP: rs6311 | |
|---|---|
| Name(s) | -1438G/A, -1438A/G, A-1438G, G-1438A |
| Gene | HTR2A |
| Chromosome | 13 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 6311 |
| HapMap | 6311 |
| SNPedia | 6311 |
| SzGene | Meta-analysis Overview |
In genetics, rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is a neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory[1][2][3][4] or with a psychological task measuring impulsive behavior.[5] The SNP has also been investigated in rheumatology studies.[6][7]
Some research studies may refer to this gene variation as a C/T SNP,[2] while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.[8][9][10]
(As of 2008), meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.[11]
rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene.
References
- ↑ "Serotonergic genes and personality traits in the Korean population". Neurosci. Lett. 354 (1): 2–5. January 2004. doi:10.1016/S0304-3940(03)00753-5. PMID 14698468.
- ↑ 2.0 2.1 "Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene". Journal of Affective Disorders 96 (1–2): 75–81. November 2006. doi:10.1016/j.jad.2006.05.016. PMID 16814396.
- ↑ "Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder". Am J Med Genet B 144B (4): 424–429. June 2007. doi:10.1002/ajmg.b.30412. PMID 17440930.
- ↑ "5-HT2A SNPs and the Temperament and Character Inventory". Progress in Neuro-Psychopharmacology and Biological Psychiatry 31 (6): 1275–1281. August 2007. doi:10.1016/j.pnpbp.2007.05.008. PMID 17590256.
- ↑ "Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior". Psychopharmacology 187 (1): 30–35. July 2006. doi:10.1007/s00213-006-0398-z. PMID 16767413.
- ↑ "Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility". Rheumatology International 28 (7): 685–691. May 2008. doi:10.1007/s00296-008-0525-8. PMID 18196244.
- ↑ "Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis". Ann. Rheum. Dis. 67 (8): 1111–5. 2007. doi:10.1136/ard.2007.074948. PMID 18006541.
- ↑ "Longitudinal change in memory performance associated with HTR2A polymorphism". Neurobiology of Aging 27 (1): 150–154. January 2006. doi:10.1016/j.neurobiolaging.2004.12.009. PMID 16298250.
- ↑ "Serotonin Receptor 2A (HTR2A) Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome". Metabolic Syndrome and Related Disorders 5 (4): 323–330. December 2007. doi:10.1089/met.2007.0008. PMID 18370802.
- ↑ "Association study between obsessive–compulsive disorder and serotonergic candidate genes". Progress in Neuro-Psychopharmacology and Biological Psychiatry 32 (3): 765–770. April 2008. doi:10.1016/j.pnpbp.2007.12.005. PMID 18191318.
- ↑ "Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs6311". Schizophrenia Research Forum. http://www.schizophreniaforum.org/res/sczgene/meta.asp?geneID=293.
 |  |
