Biology:SECISBP2
 Generic protein structure example |
SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.[1][2]
Function
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.[2]
Clinical significance
Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.[2]
See also
References
- ↑ "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- ↑ 2.0 2.1 2.2 "Entrez Gene: SECISBP2 SECIS binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79048.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs". The EMBO Journal 19 (2): 306–14. January 2000. doi:10.1093/emboj/19.2.306. PMID 10637234.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy". The EMBO Journal 19 (24): 6882–90. December 2000. doi:10.1093/emboj/19.24.6882. PMID 11118223.
- "cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2". Gene 291 (1–2): 279–85. May 2002. doi:10.1016/S0378-1119(02)00629-7. PMID 12095701.
- "The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding". RNA 8 (10): 1308–18. October 2002. doi:10.1017/S1355838202020034. PMID 12403468.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nature Genetics 37 (11): 1247–52. November 2005. doi:10.1038/ng1654. PMID 16228000.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415-8. January 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function". Molecular and Cellular Biology 26 (13): 4895–910. July 2006. doi:10.1128/MCB.02284-05. PMID 16782878.
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