Biology:SENP8
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Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.[1][2][3]
NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM][3]
References
- ↑ "NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins". J Biol Chem 278 (28): 25637–43. Jul 2003. doi:10.1074/jbc.M212948200. PMID 12730221.
- ↑ "Identification and characterization of DEN1, a deneddylase of the ULP family". J Biol Chem 278 (31): 28892–900. Jul 2003. doi:10.1074/jbc.M302890200. PMID 12759362.
- ↑ 3.0 3.1 "Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=123228.
Further reading
- "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.". J. Biol. Chem. 282 (36): 26217–24. 2007. doi:10.1074/jbc.M702444200. PMID 17591783.
- "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.". Biochem. J. 409 (2): 461–9. 2008. doi:10.1042/BJ20070940. PMID 17916063. https://semanticscholar.org/paper/a4cab9b2a49fbac17ecdbc224703a981e917015f.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.". J. Biol. Chem. 278 (31): 28882–91. 2003. doi:10.1074/jbc.M302888200. PMID 12759363.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.". Cell 118 (1): 83–97. 2004. doi:10.1016/j.cell.2004.06.016. PMID 15242646.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1.". J. Mol. Biol. 345 (1): 141–51. 2005. doi:10.1016/j.jmb.2004.10.022. PMID 15567417.
- "Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.". EMBO J. 24 (7): 1341–51. 2005. doi:10.1038/sj.emboj.7600628. PMID 15775960.
External links
- Overview of all the structural information available in the PDB for UniProt: Q96LD8 (Sentrin-specific protease 8) at the PDBe-KB.
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