Biology:SFMBT1

Short description: Protein-coding gene in the species Homo sapiens

Scm-like with four mbt domains 1 is a protein that in humans is encoded by the SFMBT1 gene.

Function

This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012].

Further reading

• Zhang, J.; Bonasio, R.; Strino, F.; Kluger, Y.; Holloway, J. K.; Modzelewski, A. J.; Cohen, P. E.; Reinberg, D. (2013). "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors". Genes & Development 27 (7): 749–766. doi:10.1101/gad.210963.112. PMID 23592795. 
• Köttgen, A.; Albrecht, E.; Teumer, A.; Vitart, V.; Krumsiek, J.; Hundertmark, C.; Pistis, G.; Ruggiero, D. et al. (2012). "Genome-wide association analyses identify 18 new loci associated with serum urate concentrations". Nature Genetics 45 (2): 145–154. doi:10.1038/ng.2500. PMID 23263486. 
• Kato, T.; Sato, H.; Emi, M.; Seino, T.; Arawaka, S.; Iseki, C.; Takahashi, Y.; Wada, M. et al. (2011). "Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: A community-based study". Internal Medicine (Tokyo, Japan) 50 (4): 297–303. doi:10.2169/internalmedicine.50.4505. PMID 21325761. 
• Lin, S.; Shen, H.; Li, J. -L.; Tang, S.; Gu, Y.; Chen, Z.; Hu, C.; Rice, J. C. et al. (2013). "Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program". Journal of Biological Chemistry 288 (9): 6238–6247. doi:10.1074/jbc.M112.429605. PMID 23349461. 
• Wu, S.; Trievel, R. C.; Rice, J. C. (2007). "Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3". FEBS Letters 581 (17): 3289–3296. doi:10.1016/j.febslet.2007.06.025. PMID 17599839. 
• Yang, H. C.; Liang, Y. J.; Chen, J. W.; Chiang, K. M.; Chung, C. M.; Ho, H. Y.; Ting, C. T.; Lin, T. H. et al. (2012). Mariño-Ramírez, Leonardo. ed. "Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study". PLOS ONE 7 (3): e32907. doi:10.1371/journal.pone.0032907. PMID 22479346. Bibcode: 2012PLoSO...732907Y. 
• Morel, S.; Lévy, F.; Burlet-Schiltz, O.; Brasseur, F.; Probst-Kepper, M.; Peitrequin, A. L.; Monsarrat, B.; Van Velthoven, R. et al. (2000). "Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells". Immunity 12 (1): 107–117. doi:10.1016/S1074-7613(00)80163-6. PMID 10661410. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.