Biology:SGK3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.

Function

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

In melanocytic cells SGK3 gene expression may be regulated by MITF.

Interactions

SGK3 has been shown to interact with GSK3B.

Further reading

• "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE 2001 (108): RE17. 2002. doi:10.1126/stke.2001.108.re17. PMID 11707620. 
• "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. 2002. doi:10.1021/cr000110o. PMID 11749387. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 11960–5. 2000. doi:10.1073/pnas.220413597. PMID 11035810. Bibcode: 2000PNAS...9711960F. 
• "Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides". J. Cell Biol. 154 (4): 699–705. 2001. doi:10.1083/jcb.200105089. PMID 11514587. 
• "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. 2002. doi:10.1074/jbc.M107768200. PMID 11751930. 
• "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway". Mol. Cell. Biol. 22 (7): 2099–110. 2002. doi:10.1128/MCB.22.7.2099-2110.2002. PMID 11884598. 
• "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. 2002. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501. 
• "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)". J. Biol. Chem. 277 (45): 43064–70. 2003. doi:10.1074/jbc.M207604200. PMID 12218062. 
• "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. 2003. doi:10.1007/s00424-002-0873-2. PMID 12397388. 
• "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms". Kidney Blood Press. Res. 25 (6): 370–4. 2003. doi:10.1159/000068699. PMID 12590200. 
• "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. 2003. doi:10.1007/s00424-002-0993-8. PMID 12632189. 
• "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. 2003. doi:10.1007/s00424-002-0982-y. PMID 12634932. 
• "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner". J. Biol. Chem. 279 (6): 4794–801. 2004. doi:10.1074/jbc.M309653200. PMID 14604990.