Biology:SIVA1
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Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.[1][2] This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[2]
Interactions
SIVA1 has been shown to interact with CD27.[1]
Siva (protein)
Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. [3]
See also
- Siva (protein)
References
- ↑ 1.0 1.1 "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A 94 (12): 6346–51. Jul 1997. doi:10.1073/pnas.94.12.6346. PMID 9177220. Bibcode: 1997PNAS...94.6346P.
- ↑ 2.0 2.1 "Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10572.
- ↑ "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. July 2004. doi:10.1074/jbc.M400376200. PMID 15105421. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=15105421.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva". J. Virol. 74 (9): 4284–90. 2000. doi:10.1128/JVI.74.9.4284-4290.2000. PMID 10756043.
- "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. 2001. doi:10.1074/jbc.C100050200. PMID 11278261.
- "The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva". Virology 289 (1): 15–22. 2001. doi:10.1006/viro.2001.1082. PMID 11601913.
- "CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors". Int. J. Cancer 98 (3): 352–6. 2002. doi:10.1002/ijc.10207. PMID 11920585.
- "Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6925–30. 2002. doi:10.1073/pnas.102182299. PMID 12011449. Bibcode: 2002PNAS...99.6925X.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "GITR interacts with the pro-apoptotic protein Siva and induces apoptosis". Cell Death Differ. 9 (12): 1382–4. 2003. doi:10.1038/sj.cdd.4401140. PMID 12478477.
- "The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis". Apoptosis 9 (1): 83–95. 2004. doi:10.1023/B:APPT.0000012125.01799.4c. PMID 14739602.
- "Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway". J. Immunol. 172 (7): 4008–17. 2004. doi:10.4049/jimmunol.172.7.4008. PMID 15034012.
- "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. 2004. doi:10.1074/jbc.M400376200. PMID 15105421.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2". Cancer Res. 65 (12): 5301–9. 2005. doi:10.1158/0008-5472.CAN-04-3270. PMID 15958577.
- "Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD)". Oncogene 25 (24): 3458–62. 2006. doi:10.1038/sj.onc.1209381. PMID 16491128.
- "The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22". Mol. Cell. Biochem. 287 (1–2): 147–55. 2006. doi:10.1007/s11010-005-9082-6. PMID 16683188.
- "Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes". J. Cell. Physiol. 212 (1): 118–25. 2007. doi:10.1002/jcp.21011. PMID 17348035.
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