Biology:SLAMF6

Generic protein structure example

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Further reading

• "Regulation of NK cell activity by 2B4, NTB-A and CRACC.". Front. Biosci. 13 (13): 956–65. 2007. doi:10.2741/2735. PMID 17981603. 
• "Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure". Cell. Immunol. 86 (2): 381–92. 1984. doi:10.1016/0008-8749(84)90393-9. PMID 6610481. 
• "Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function". Mol. Cell. Biol. 16 (9): 5026–35. 1996. doi:10.1128/MCB.16.9.5026. PMID 8756661. 
• "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation". J. Immunol. 157 (9): 3828–37. 1996. PMID 8892612. 
• "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. 2000. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. 2003. doi:10.1074/jbc.M301569200. PMID 12621057. 
• "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. 171 (5): 2485–95. 2003. doi:10.4049/jimmunol.171.5.2485. PMID 12928397. 
• "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309. 
• "NTB-A, a new activating receptor in T cells that regulates autoimmune disease". J. Biol. Chem. 279 (18): 18662–9. 2004. doi:10.1074/jbc.M312313200. PMID 14988414. 
• "Cutting edge: NTB-A activates NK cells via homophilic interaction". J. Immunol. 172 (11): 6524–7. 2004. doi:10.4049/jimmunol.172.11.6524. PMID 15153464. 
• "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells". Int. Immunol. 18 (2): 241–7. 2006. doi:10.1093/intimm/dxh358. PMID 16410313. 
• "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G. 
• "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells". J. Immunol. 177 (5): 3170–7. 2006. doi:10.4049/jimmunol.177.5.3170. PMID 16920955. 
• "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family". Immunity 25 (4): 559–70. 2006. doi:10.1016/j.immuni.2006.06.020. PMID 17045824. 
• "Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells". J. Virol. 81 (18): 9707–17. 2007. doi:10.1128/JVI.00887-07. PMID 17609265.