Biology:SMARCA2
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Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.[1][2]
Function
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.[2]
Interactions
SMARCA2 has been shown to interact with:
- ACTL6A,[3][4][5]
- ARID1B,[6]
- CEBPB,[7]
- POLR2A,[3][8][9]
- Prohibitin,[10]
- SIN3A,[8]
- SMARCB1,[3][8]
- SMARCC1,[3][8] and
- SS18.[11]
- Nicolaides Baraitser Syndrome (NCBRS)
References
- ↑ "Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization". Mammalian Genome 5 (4): 241–3. Apr 1994. doi:10.1007/BF00360554. PMID 8012116.
- ↑ 2.0 2.1 "Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595.
- ↑ 3.0 3.1 3.2 3.3 "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal 15 (19): 5370–82. Oct 1996. doi:10.1002/j.1460-2075.1996.tb00921.x. PMID 8895581.
- ↑ "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Molecular and Cellular Biology 22 (5): 1307–16. Mar 2002. doi:10.1128/mcb.22.5.1307-1316.2002. PMID 11839798.
- ↑ "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochemical and Biophysical Research Communications 299 (2): 328–34. Nov 2002. doi:10.1016/s0006-291x(02)02637-2. PMID 12437990.
- ↑ "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". The Journal of Biological Chemistry 277 (44): 41674–85. Nov 2002. doi:10.1074/jbc.M205961200. PMID 12200431.
- ↑ "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Molecular Cell 4 (5): 735–43. Nov 1999. doi:10.1016/s1097-2765(00)80384-6. PMID 10619021.
- ↑ 8.0 8.1 8.2 8.3 "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes & Development 15 (5): 603–18. Mar 2001. doi:10.1101/gad.872801. PMID 11238380.
- ↑ "A human RNA polymerase II complex containing factors that modify chromatin structure". Molecular and Cellular Biology 18 (9): 5355–63. Sep 1998. doi:10.1128/MCB.18.9.5355. PMID 9710619.
- ↑ "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". The EMBO Journal 21 (12): 3019–28. Jun 2002. doi:10.1093/emboj/cdf302. PMID 12065415.
- ↑ "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene 22 (50): 8156–67. Nov 2003. doi:10.1038/sj.onc.1207031. PMID 14603256.
Further reading
- "A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains". Molecular & General Genetics 248 (4): 491–8. Aug 1995. doi:10.1007/BF02191650. PMID 7565614.
- "Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor". Nucleic Acids Research 22 (10): 1815–20. May 1994. doi:10.1093/nar/22.10.1815. PMID 8208605.
- "A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor". The EMBO Journal 12 (11): 4279–90. Nov 1993. doi:10.1002/j.1460-2075.1993.tb06112.x. PMID 8223438.
- "The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis". The EMBO Journal 15 (13): 3394–402. Jul 1996. doi:10.1002/j.1460-2075.1996.tb00705.x. PMID 8670841.
- "Diversity and specialization of mammalian SWI/SNF complexes". Genes & Development 10 (17): 2117–30. Sep 1996. doi:10.1101/gad.10.17.2117. PMID 8804307.
- "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal 15 (19): 5370–82. Oct 1996. doi:10.1002/j.1460-2075.1996.tb00921.x. PMID 8895581.
- "Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2". Gene 188 (1): 95–100. Mar 1997. doi:10.1016/S0378-1119(96)00785-8. PMID 9099865.
- "A human RNA polymerase II complex containing factors that modify chromatin structure". Molecular and Cellular Biology 18 (9): 5355–63. Sep 1998. doi:10.1128/MCB.18.9.5355. PMID 9710619.
- "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Human Molecular Genetics 8 (4): 585–91. Apr 1999. doi:10.1093/hmg/8.4.585. PMID 10072425.
- "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Molecular Cell 3 (2): 247–53. Feb 1999. doi:10.1016/S1097-2765(00)80315-9. PMID 10078207.
- "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Research 60 (13): 3612–22. Jul 2000. PMID 10910076.
- "Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases". Molecular and Cellular Biology 20 (17): 6380–9. Sep 2000. doi:10.1128/MCB.20.17.6380-6389.2000. PMID 10938115.
- "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes". Proceedings of the National Academy of Sciences of the United States of America 97 (24): 13015–20. Nov 2000. doi:10.1073/pnas.240208597. PMID 11078522. Bibcode: 2000PNAS...9713015X.
- "Expression of chromatin remodeling factors during neural differentiation". Journal of Biochemistry 129 (1): 43–9. Jan 2001. doi:10.1093/oxfordjournals.jbchem.a002834. PMID 11134956.
- "Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation". Nature Genetics 27 (2): 187–90. Feb 2001. doi:10.1038/84826. PMID 11175787.
- "The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes". Development 128 (8): 1429–41. Apr 2001. doi:10.1242/dev.128.8.1429. PMID 11262242.
- "Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling". The Journal of Biological Chemistry 277 (7): 4782–9. Feb 2002. doi:10.1074/jbc.M109532200. PMID 11719516.
- "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry 277 (7): 5498–505. Feb 2002. doi:10.1074/jbc.M108702200. PMID 11734557.
- "Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex". The Journal of Biological Chemistry 277 (18): 15859–64. May 2002. doi:10.1074/jbc.M112421200. PMID 11850427.
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