Biology:SMIM11
 Generic protein structure example |
Small integral membrane protein 11 is a protein which in humans is encoded by the SMIM11 gene.[1][2]
Gene
Locus
SMIM11 is located on the plus strand of chromosome 21 and has 4 exons.[2]
Expression
The expression of SMIM11 is highest in the brain, thyroid, and stomach, though it is also expressed in many other tissues.[2]
mRNA
There are no known transcript variants or isoforms of SMIM11.[3]
Protein
The SMIM11 protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9.[4] The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells.[5][6]
Domains, Motifs, and Post-translational Modifications
SMIM11 contains a transmembrane domain.[7] The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine[8][9]
Secondary Structure and Tertiary Structure
The protein is composed mostly of alpha-helices.[10] The N-terminus of SMIM11 sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell.[11]
Quaternary Structure and Protein Interactions
Experimentally-determined protein interactions for SMIM11 have not yet been identified.[12]
Homology and Evolution
Paralogs
No paralogs or paralogous domains exist for SMIM11
Orthologs
SMIM11 has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish.[13]
References
- ↑ "P58511 · SIM11_HUMAN". UniProt. https://www.uniprot.org/uniprot/P58511.
- ↑ 2.0 2.1 2.2 "SMIM11 small integral membrane protein 11 [ Homo sapiens (human) "]. National Center for Biotechnology Information, U.S. National Library of Medicine. https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&list_uids=54065.
- ↑ "SMIM11A Protein Coding". https://www.genecards.org/cgi-bin/carddisp.pl?gene=SMIM11A#snp.
- ↑ "Compute pI/Mw Tool Expasy". https://web.expasy.org/compute_pi/.
- ↑ "PSORT II Server". https://psort.hgc.jp/form2.html.
- ↑ "Immunohistochemistry of SMIM11A: The Human Protein Atlas". https://www.proteinatlas.org/ENSG00000205670-SMIM11A/antibody.
- ↑ "Homo sapiens small integral membrane protein 11A (SMIM11A), mRNA". NCBI (National Center for Biotechnology Information). https://www.ncbi.nlm.nih.gov/nuccore/NM_058182.4?report=genbank.
- ↑ "iPTMnet Report for P58511 (SMIM11A)". https://research.bioinformatics.udel.edu/iptmnet/entry/P58511/.
- ↑ "NetPhos 3.1 Server". http://www.cbs.dtu.dk/services/NetPhos/.
- ↑ "Phyre2 Results". http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/b05a738fd4deeae0/summary.html.
- ↑ "TMHHM Server". http://www.cbs.dtu.dk/services/TMHMM-2.0/.
- ↑ "STRING FAM165B". https://string-db.org/cgi/network.pl?taskId=yBcjFuOJy5Y0.
- ↑ "NCBI Protein Blast". https://blast.ncbi.nlm.nih.gov/Blast.cgi.
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