Biology:SOX2OT
From HandWiki
 Generic protein structure example |
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies within one of the introns of SOX2OT.[1] SOX2OT and SOX2DOT (an isoform of SOXOT transcribed from a distal highly conserved element) are expressed in zones of neurogenesis within the brain. It is associated with central nervous system structures in zebrafish and chicken embryonic brains, and is dynamically regulated during embryogenesis.[2] SOX2OT may play a role in vertebrate development.[2]
See also
- Long noncoding RNA
References
- ↑ "Mutations in SOX2 cause anophthalmia". Nat. Genet. 33 (4): 461–3. April 2003. doi:10.1038/ng1120. PMID 12612584.
- ↑ 2.0 2.1 "Complex architecture and regulated expression of the Sox2ot locus during vertebrate development". RNA 15 (11): 2013–27. November 2009. doi:10.1261/rna.1705309. PMID 19767420.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
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