Biology:SOX30

Short description: Protein-coding gene in the species Homo sapiens

SRY (sex determining region Y)-box 30 is a protein that in humans is encoded by the SOX30 gene.

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Further reading

• Koopman, P; Schepers, G; Brenner, S; Venkatesh, B (2004). "Origin and diversity of the SOX transcription factor gene family: Genome-wide analysis in Fugu rubripes". Gene 328: 177–86. doi:10.1016/j.gene.2003.12.008. PMID 15019997. 
• Osaki, E; Nishina, Y; Inazawa, J; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Ohsugi, M; Tezuka, T et al. (1999). "Identification of a novel Sry-related gene and its germ cell-specific expression". Nucleic Acids Research 27 (12): 2503–10. doi:10.1093/nar/27.12.2503. PMID 10359848. 
• Fan, B. J.; Wang, D. Y.; Tham, C. C.; Lam, D. S.; Pang, C. P. (2008). "Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone". Investigative Ophthalmology & Visual Science 49 (5): 1886–97. doi:10.1167/iovs.07-0414. PMID 18436822. 
• Bullejos, M; Díaz de la Guardia R; Barragán, M. J.; Sánchez, A (2000). "HMG-box sequences from microbats homologous to the human SOX30 HMG-box". Genetica 110 (2): 157–62. doi:10.1023/A:1017914005677. PMID 11678506. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.