Biology:SSH2

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.[1][2][3]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][3]

References

  1. "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell 108 (2): 233–46. Feb 2002. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. Feb 2001. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  3. 3.0 3.1 "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85464. 

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q76I76 (Protein phosphatase Slingshot homolog 2) at the PDBe-KB.