Biology:SSH2
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Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.[1][2][3]
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][3]
References
- ↑ "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell 108 (2): 233–46. Feb 2002. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213.
- ↑ "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. Feb 2001. doi:10.1093/dnares/7.6.347. PMID 11214970.
- ↑ 3.0 3.1 "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85464.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of genes expressed during myocardial development.". Chin. Med. J. 116 (9): 1329–32. 2004. PMID 14527359.
- "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.". Genes Cells 8 (10): 811–24. 2004. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell. Proteomics 3 (11): 1093–101. 2005. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.". EMBO J. 24 (3): 473–86. 2005. doi:10.1038/sj.emboj.7600543. PMID 15660133.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.". J. Biol. Chem. 282 (44): 32520–8. 2007. doi:10.1074/jbc.M707041200. PMID 17848544.
External links
- Overview of all the structural information available in the PDB for UniProt: Q76I76 (Protein phosphatase Slingshot homolog 2) at the PDBe-KB.
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