Biology:SSMEM1
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Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene.[1]
Gene
The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45.[2][3] Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.[4] The human mRNA transcript is 1171 bp long with three exons.[5]
Aliases
In humans, SSMEM1 is also referred to as C7orf45.[4] Human SSMEM1 has a clone name of FLJ40316.[4]
Expression
In humans, SSMEM1 is highly expressed in the testes.[6][failed verification][7][8] In mice, SSMEM1 is expressed in the brain.[9]
Protein
In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55.[1] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243).[1] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long.[1] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.[1][10]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "serine-rich single-pass membrane protein 1 [Homo sapiens"]. Protein. NCBI. 26 August 2016. NP_660311.1. https://www.ncbi.nlm.nih.gov/protein/NP_660311.1. Retrieved 2016-12-16.
- ↑ "Showing 9.782 kbp from Chr7, positions 129,233,084 to 129,242,865". The Chromosome 7 Annotation Project. June 2004. Landmark or Region: Gene:C7orf45|NM_145268.2. http://www.chr7.org/cgi-bin/gbrowse/gbrowse/chr7_v2/?name=Gene%3AC7orf45%7CNM_145268.2;addlabel=NCBI_RefSeq.
- ↑ "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–772. 2003. doi:10.1126/science.1083423. PMID 12690205. Bibcode: 2003Sci...300..767S.
- ↑ 4.0 4.1 4.2 "SSMEM1 serine rich single-pass membrane protein 1 [ Homo sapiens (human) "]. Gene. NCBI. 6 December 2016. 136263. https://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=21687171. Retrieved 2016-12-16.
- ↑ "Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1), mRNA". Nucleotide. NCBI. 26 August 2016. NM_145268.3. https://www.ncbi.nlm.nih.gov/nuccore/197304739. Retrieved 2016-12-16.
- ↑ "United States Patent: 8586006 - Organ-specific proteins and methods of their use". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/8586006.
- ↑ "Est Profile - Hs.351816". UniGene. NCBI. 2016. https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.351816.
- ↑ "GDS3834 / 4246". https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3834:4246.
- ↑ "Gene Detail :: Allen Brain Atlas: Mouse Brain". http://mouse.brain-map.org/gene/show/51488.
- ↑ "SSMEM1 (human)". http://www.phosphosite.org/proteinAction.do?id=13271515&showAllSites=true.
![]() | Original source: https://en.wikipedia.org/wiki/SSMEM1.
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