Biology:ST6GALNAC1
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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene.[1] This enzyme adds a N-Acetylneuraminic acid (Sialic Acid/Neu5Ac) to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.[2][3]
References
- ↑ "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55808.
- ↑ "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology 27 (9): 1207–1219.e9. June 2020. doi:10.1016/j.chembiol.2020.06.007. PMID 32610041.
- ↑ "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies". Scientific Reports 9 (1): 16641. November 2019. doi:10.1038/s41598-019-53052-1. PMID 31719620. Bibcode: 2019NatSR...916641Y.
Further reading
- "Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV". The Journal of Biological Chemistry 274 (17): 11958–67. April 1999. doi:10.1074/jbc.274.17.11958. PMID 10207017.
- "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens". Glycobiology 9 (11): 1213–24. November 1999. doi:10.1093/glycob/9.11.1213. PMID 10536037.
- "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells". Biochimie 85 (3–4): 311–21. 2004. doi:10.1016/S0300-9084(03)00080-4. PMID 12770770.
- "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA". Glycoconjugate Journal 18 (11–12): 883–93. 2003. doi:10.1023/A:1022200525695. PMID 12820722.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. October 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer". The Journal of Biological Chemistry 281 (6): 3586–94. February 2006. doi:10.1074/jbc.M511826200. PMID 16319059.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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