Biology:STEAP4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.

Function

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene may be involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene

Further reading

• "Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans". Acta Pharmacologica Sinica 29 (5): 587–92. May 2008. doi:10.1111/j.1745-7254.2008.00793.x. PMID 18430367. 
• "[Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics 28 (1): 64–8. February 2011. doi:10.3760/cma.j.issn.1003-9406.2011.01.015. PMID 21287513. 
• "Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro". FEBS Letters 583 (7): 1196–200. April 2009. doi:10.1016/j.febslet.2009.03.015. PMID 19289123. 
• "[Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics 28 (1): 78–82. February 2011. doi:10.3760/cma.j.issn.1003-9406.2011.01.018. PMID 21287516. 
• "Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population". Archives of Medical Research 41 (6): 449–56. August 2010. doi:10.1016/j.arcmed.2010.08.006. PMID 21044749. 
• "Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis". Modern Rheumatology 22 (1): 128–36. February 2012. doi:10.1007/s10165-011-0475-y. PMID 21633911. 
• "A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population". Chinese Medical Journal 124 (14): 2096–100. July 2011. PMID 21933608. 
• "A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study)". Obesity 19 (3): 612–7. March 2011. doi:10.1038/oby.2010.219. PMID 20885390. 
• "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene 24 (31): 4934–45. July 2005. doi:10.1038/sj.onc.1208677. PMID 15897894. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.