Biology:STX4
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Short description: Protein-coding gene in the species Homo sapiens
Generic protein structure example |
Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.[1][2][3]
Interactions
STX4 has been shown to interact with:
- Gelsolin,[4]
- NAPA,[5]
- RAB4A,[6]
- SNAP-25,[7][8][9][10]
- SNAP23,[8][10][11][12][13][14][15][16]
- STXBP1,[7][17]
- STXBP5,[18]
- Syntaxin binding protein 3,[17][18]
- TXLNB,[19]
- VAMP2,[9][14][20][21]
- VAMP3,[5][11][14][22] and
- Vesicle-associated membrane protein 8.[14][22]
References
- ↑ "Isolation and sequence analysis of the human syntaxin-encoding gene". Gene 143 (2): 303–4. Jun 1994. doi:10.1016/0378-1119(94)90117-1. PMID 8206394.
- ↑ "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Molecular Biology of the Cell 17 (2): 977–89. Feb 2006. doi:10.1091/mbc.E05-05-0462. PMID 16339081.
- ↑ "Entrez Gene: STX4 Syntaxin 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6810.
- ↑ "Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis". Molecular Endocrinology (Baltimore, Md.) 26 (1): 128–41. January 2012. doi:10.1210/me.2011-1112. PMID 22108804.
- ↑ 5.0 5.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. Feb 2001. doi:10.1074/jbc.M003883200. PMID 11063739.
- ↑ 7.0 7.1 "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry 270 (22): 13022–8. Jun 1995. doi:10.1074/jbc.270.22.13022. PMID 7768895.
- ↑ 8.0 8.1 "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry 271 (23): 13300–3. Jun 1996. doi:10.1074/jbc.271.23.13300. PMID 8663154.
- ↑ 9.0 9.1 "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. Apr 1999. doi:10.1182/blood.V93.8.2617. PMID 10194441.
- ↑ 10.0 10.1 "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry 273 (51): 34171–9. Dec 1998. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- ↑ 11.0 11.1 "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology 48 (8): 597–604. Aug 2003. doi:10.1016/s0003-9969(03)00116-x. PMID 12828989.
- ↑ "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry 278 (22): 19791–7. May 2003. doi:10.1074/jbc.M212250200. PMID 12651853.
- ↑ "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. May 1997. doi:10.1006/bbrc.1997.6560. PMID 9168999.
- ↑ 14.0 14.1 14.2 14.3 "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. Jun 2000. doi:10.4049/jimmunol.164.11.5850. PMID 10820264.
- ↑ "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2". The Journal of Biological Chemistry 275 (11): 8240–7. Mar 2000. doi:10.1074/jbc.275.11.8240. PMID 10713150.
- ↑ "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". The Journal of Biological Chemistry 278 (15): 13462–7. Apr 2003. doi:10.1074/jbc.M210483200. PMID 12556468.
- ↑ 17.0 17.1 "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal 374 (Pt 1): 207–17. Aug 2003. doi:10.1042/BJ20030610. PMID 12773094.
- ↑ 18.0 18.1 "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry 278 (37): 35093–101. Sep 2003. doi:10.1074/jbc.M304261200. PMID 12832401.
- ↑ "Identification and characterization of taxilin isoforms". Biochemical and Biophysical Research Communications 319 (3): 936–43. Jul 2004. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072.
- ↑ "Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils". Journal of Immunology 170 (2): 1034–42. Jan 2003. doi:10.4049/jimmunol.170.2.1034. PMID 12517971.
- ↑ "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (3): 945–54. Aug 1996. doi:10.1042/bj3170945. PMID 8760387.
- ↑ 22.0 22.1 "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. Aug 2002. doi:10.1182/blood.v100.3.1081. PMID 12130530.
Further reading
- "The syntaxin family of vesicular transport receptors". Cell 74 (5): 863–73. Sep 1993. doi:10.1016/0092-8674(93)90466-4. PMID 7690687.
- "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. Jun 1995. doi:10.1038/375594a0. PMID 7791877.
- "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (Pt 3): 945–54. Aug 1996. doi:10.1042/bj3170945. PMID 8760387.
- "Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking". The Journal of Clinical Investigation 98 (4): 906–13. Aug 1996. doi:10.1172/JCI118873. PMID 8770861.
- "Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein". The Biochemical Journal 320 (Pt 2): 429–36. Dec 1996. doi:10.1042/bj3200429. PMID 8973549.
- "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". The Journal of Biological Chemistry 272 (10): 6179–86. Mar 1997. doi:10.1074/jbc.272.10.6179. PMID 9045631.
- "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. May 1997. doi:10.1006/bbrc.1997.6560. PMID 9168999.
- "SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles". The American Journal of Physiology 275 (5 Pt 2): F752-60. Nov 1998. doi:10.1152/ajprenal.1998.275.5.F752. PMID 9815132.
- "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. Apr 1999. doi:10.1182/blood.V93.8.2617. PMID 10194441.
- "Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes". Molecular Cell 3 (6): 751–60. Jun 1999. doi:10.1016/S1097-2765(01)80007-1. PMID 10394363.
- "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Molecular Biology of the Cell 10 (7): 2285–95. Jul 1999. doi:10.1091/mbc.10.7.2285. PMID 10397765.
- "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer 83 (4): 456–64. Nov 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. Jun 2000. doi:10.4049/jimmunol.164.11.5850. PMID 10820264.
- "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. Feb 2001. doi:10.1074/jbc.M003883200. PMID 11063739.
- "Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis". The Journal of Allergy and Clinical Immunology 109 (2): 299–306. Feb 2002. doi:10.1067/mai.2002.121453. PMID 11842301.
- "A prototypic platelet septin and its participation in secretion". Proceedings of the National Academy of Sciences of the United States of America 99 (5): 3064–9. Mar 2002. doi:10.1073/pnas.052715199. PMID 11880646.
- "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils". Journal of Cell Science 115 (Pt 6): 1321–30. Mar 2002. doi:10.1242/jcs.115.6.1321. PMID 11884531.
- "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. Aug 2002. doi:10.1182/blood.V100.3.1081. PMID 12130530.
- "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly". The Journal of Biological Chemistry 277 (31): 28271–9. Aug 2002. doi:10.1074/jbc.M204929200. PMID 12145319.
External links
- Overview of all the structural information available in the PDB for UniProt: P70452 (Mouse Syntaxin-4) at the PDBe-KB.