Biology:SYNJ2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene.

Function

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

Further reading

• "Longevity candidate genes and their association with personality traits in the elderly". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 159B (2): 192–200. March 2012. doi:10.1002/ajmg.b.32013. PMID 22213687. 
• "The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation". Addiction Biology 18 (5): 846–50. September 2013. doi:10.1111/j.1369-1600.2012.00478.x. PMID 22823124. 
• "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". The Journal of Biological Chemistry 278 (6): 4160–7. February 2003. doi:10.1074/jbc.M208568200. PMID 12456676. 
• "Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells". Leukemia 17 (12): 2467–73. December 2003. doi:10.1038/sj.leu.2403174. PMID 14562116. 
• "Regulation of synaptojanin 2 5'-phosphatase activity by Src". Cell Adhesion & Migration 6 (6): 518–25. 2012. doi:10.4161/cam.22139. PMID 23076136. 
• "Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks". PLOS ONE 7 (4): e36023. 2012. doi:10.1371/journal.pone.0036023. PMID 22558309. Bibcode: 2012PLoSO...736023W. 
• "Genome-wide search for gene-gene interactions in colorectal cancer". PLOS ONE 7 (12): e52535. 2012. doi:10.1371/journal.pone.0052535. PMID 23300701. Bibcode: 2012PLoSO...752535J. 
• "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle". The Journal of Biological Chemistry 286 (26): 23521–32. July 2011. doi:10.1074/jbc.M111.220178. PMID 21555518. 
• "Role of synaptojanin 2 in glioma cell migration and invasion". Cancer Research 64 (22): 8271–5. November 2004. doi:10.1158/0008-5472.CAN-04-2097. PMID 15548694. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.