Biology:Inositol-polyphosphate 5-phosphatase
| Inositol-polyphosphate 5-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.56 | ||||||||
| CAS number | 106283-14-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme Inositol-polyphosphate 5-phosphatase (EC 3.1.3.56, systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase; other names type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase)[1][2][3][4] catalyses the following reaction
- (1) D-myo-inositol 1,4,5-trisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] myo-inositol 1,4-bisphosphate + phosphate
- (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1D-myo-inositol 1,3,4-trisphosphate + phosphate
Ten mammalian isoforms are known.[5]
References
- ↑ "The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane". The Biochemical Journal 203 (1): 169–77. April 1982. doi:10.1042/bj2030169. PMID 6285891.
- ↑ "Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain". European Journal of Biochemistry 181 (2): 317–22. May 1989. doi:10.1111/j.1432-1033.1989.tb14726.x. PMID 2540972.
- ↑ Woscholski, R.; Parker, P.J. (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates". in Cockcroft, S.. Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. pp. 320–338.
- ↑ "Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase". The Biochemical Journal 300 ( Pt 1): 85–90. May 1994. doi:10.1042/bj3000085. PMID 8198557.
- ↑ "The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease". The Biochemical Journal 419 ( Pt 1): 29–49. 2009. doi:10.1042/BJ20081673. PMID 19272022.
External links
- Inositol-polyphosphate+5-phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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