Biology:Segregating site
From HandWiki
Segregating sites are positions which show differences (polymorphisms) between related genes in a sequence alignment (are not conserved).[1] Segregating sites include conservative, semi-conservative and non-conservative mutations. The proportion of segregating sites within a gene is an important statistic in population genetics since it can be used to estimate mutation rate assuming no selection. For example it is used to calculate the Tajima's D neutral evolution statistic.
See also
- Conserved sequence
- Ultra-conserved element
- Sequence alignment
- Sequence alignment software
- ClustalW
References
- ↑ Fu, YX (Oct 1995). "Statistical properties of segregating sites.". Theoretical Population Biology 48 (2): 172–97. doi:10.1006/tpbi.1995.1025. PMID 7482370.
- ↑ "Clustal FAQ #Symbols". http://www.ebi.ac.uk/Tools/msa/clustalw2/help/faq.html#23. Retrieved 8 December 2014.
Original source: https://en.wikipedia.org/wiki/Segregating site.
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