Biology:Small nucleolar RNA SNORD100
From HandWiki
| Small Nucleolar RNA SNORD100 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD100 | |
| Identifiers | |
| Symbol | SNORD100 |
| Rfam | RF00609 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
| PDB structures | PDBe |
In molecular biology, Small Nucleolar RNA SNORD100 (also known as HBII-429) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD100 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the C/D box family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] SNORD100 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue G436.[2]
References
- ↑ "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology 22 (19): 6663–8. October 2002. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ↑ "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Database issue): D158-62. January 2006. doi:10.1093/nar/gkj002. PMID 16381836.
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