Biology:Small nucleolar RNA SNORD88
| Small nucleolar RNA SNORD88 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD88 | |
| Identifiers | |
| Symbol | SNORD88 |
| Rfam | RF00604 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
| PDB structures | PDBe |
In molecular biology, Small Nucleolar RNA SNORD88 (also known as HBII-180) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD88 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the C/D box family function in directing site-specific 2′-O-methylation of substrate RNAs.[1] This snoRNA is the human orthologue of mouse snoRNA MBII-180.[2] SNORD88 is also related to mouse snoRNA MBII-211. SNORD88 is predicted to guide the 2′O-ribose methylation of 28S ribosomal RNA (rRNA) residue C3680.[3]
There is evidence that SNORD88 is processed into smaller fragments in a similar fashion to a microRNA and can suppress protein expression.[4][5]
References
- ↑ "Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro". Molecular and Cellular Biology 22 (19): 6663–6668. October 2002. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ↑ "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. June 2001. doi:10.1093/emboj/20.11.2943. PMID 11387227.
- ↑ "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Database issue): D158–162. January 2006. doi:10.1093/nar/gkj002. PMID 16381836.
- ↑ "Analysis of human small nucleolar RNAs (snoRNA) and the development of snoRNA modulator of gene expression vectors". Molecular Biology of the Cell 21 (9): 1569–1584. May 2010. doi:10.1091/mbc.E10-01-0078. PMID 20219969.
- ↑ "Identification of human miRNA precursors that resemble box C/D snoRNAs". Nucleic Acids Research 39 (9): 3879–3891. May 2011. doi:10.1093/nar/gkq1355. PMID 21247878.
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