Biology:snRNP70
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[1] that in humans is encoded by the SNRNP70 gene.[2][3] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease.[4][5] U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.
Interactions
snRNP70 has been shown to interact with ASF/SF2,[6][7] SRPK1,[8][9] and ZRANB2.[10]
Role in autoimmunity
Antibodies towards snRNP70 are associated with mixed connective tissue disease.[11]
References
- ↑ "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Research 15 (24): 10373–91. December 1987. doi:10.1093/nar/15.24.10373. PMID 2447561.
- ↑ "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=6625&rn=1.
- ↑ "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics 8 (2): 371–9. October 1990. doi:10.1016/0888-7543(90)90295-6. PMID 2147422.
- ↑ "Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease". The Journal of Biological Chemistry 289 (51): 35296–313. December 2014. doi:10.1074/jbc.M114.562959. PMID 25355317.
- ↑ "U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21". Molecular Neurodegeneration 9: 15. April 2014. doi:10.1186/1750-1326-9-15. PMID 24773620.
- ↑ "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". The EMBO Journal 17 (21): 6359–67. November 1998. doi:10.1093/emboj/17.21.6359. PMID 9799243.
- ↑ "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". The Journal of Biological Chemistry 273 (32): 20629–35. August 1998. doi:10.1074/jbc.273.32.20629. PMID 9685421.
- ↑ "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". The Journal of Cell Biology 140 (4): 737–50. February 1998. doi:10.1083/jcb.140.4.737. PMID 9472028.
- ↑ "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". The Journal of Experimental Medicine 196 (9): 1213–25. November 2002. doi:10.1084/jem.20021167. PMID 12417631.
- ↑ "ZNF265--a novel spliceosomal protein able to induce alternative splicing". The Journal of Cell Biology 154 (1): 25–32. July 2001. doi:10.1083/jcb.200010059. PMID 11448987.
- ↑ "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease". Arthritis and Rheumatism 62 (12): 3730–40. December 2010. doi:10.1002/art.27700. PMID 20722023.
Further reading
- "U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA". Molecular and Cellular Biochemistry 106 (1): 55–66. July 1991. doi:10.1007/BF00231189. PMID 1833625.
- "A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein". Cell 57 (1): 89–101. April 1989. doi:10.1016/0092-8674(89)90175-X. PMID 2467746.
- "C-reactive protein reacts with the U1 small nuclear ribonucleoprotein". Journal of Immunology 143 (8): 2553–9. October 1989. doi:10.4049/jimmunol.143.8.2553. PMID 2477447.
- "Cloning of the human cDNA for the U1 RNA-associated 70K protein". The EMBO Journal 5 (12): 3209–17. December 1986. doi:10.1002/j.1460-2075.1986.tb04631.x. PMID 3028775.
- "The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain". Molecular and Cellular Biology 14 (7): 4662–70. July 1994. doi:10.1128/MCB.14.7.4662. PMID 7516470.
- "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing". Cell 75 (6): 1061–70. December 1993. doi:10.1016/0092-8674(93)90316-I. PMID 8261509.
- "Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors". Nucleic Acids Research 21 (12): 2815–22. June 1993. doi:10.1093/nar/21.12.2815. PMID 8332490.
- "Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen". Protein Expression and Purification 6 (6): 748–56. December 1995. doi:10.1006/prep.1995.0005. PMID 8746626.
- "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology 16 (10): 5400–8. October 1996. doi:10.1128/MCB.16.10.5400. PMID 8816452.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Association of U2 snRNP with the spliceosomal complex E". Nucleic Acids Research 25 (2): 354–61. January 1997. doi:10.1093/nar/25.2.354. PMID 9016565.
- "Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus". Experimental Cell Research 235 (1): 265–73. August 1997. doi:10.1006/excr.1997.3663. PMID 9281376.
- "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Molecular and Cellular Biology 18 (2): 676–84. February 1998. doi:10.1128/MCB.18.2.676. PMID 9447963.
- "A coactivator of pre-mRNA splicing". Genes & Development 12 (7): 996–1009. April 1998. doi:10.1101/gad.12.7.996. PMID 9531537.
- "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". The Journal of Biological Chemistry 273 (32): 20629–35. August 1998. doi:10.1074/jbc.273.32.20629. PMID 9685421.
- "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics 20 (1): 46–50. September 1998. doi:10.1038/1700. PMID 9731529.
- "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". The EMBO Journal 17 (21): 6359–67. November 1998. doi:10.1093/emboj/17.21.6359. PMID 9799243.
- "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle". Nucleic Acids Research 26 (23): 5486–91. December 1998. doi:10.1093/nar/26.23.5486. PMID 9826776.
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